Lectenz Platform
Lectenz
Technologies
Lectenz is able to detect important glycan modifications independent of the sialic acid linkage (e.g.: α2,3 or α2,6 or α2,8), and shows no measurable affinity for related non-sialylated glycans.
Such a reagent currently does not exist and would greatly assist in the development and detection of glycan-based disease markers, by enabling affinity enrichment of a sample in the glycopeptides or glycoproteins of interest.
in 2 Distinct Ways:
A new class of Glycomics Reagents
The development of glycomics affinity reagents (Lectenz) from engineered carbohydrate-processing enzymes will create a new class of glycomics reagents, with defined specificities and tunable properties.
Provide Binding Energy Estimates
Employing computational simulations to provide binding energy estimates, which are being used to focus the design of the biocombinatorial libraries and enhancing the efficiency of the bio-panning process
Key
Innovation
- Tunable affinities and binding kinetics (essential for applications in an affinity matrix)
- Pre-defined, and potentially tunable, specificities – depending on the ligand employed in the directed
- Evolution strategy and on the location of the mutagenesis sites
- A platform technology that could be applied to a vast number of carbohydrate-processing enzymes
- Including glycosyl hydrolases, transferases, lyases, esterases, etc…
What Makes Us Different
Advantage of our engineered Lectenz
Unlike antibodies, our engineered Lectenz is specific to a carbohydrate sequence and can recognize a broad range of glycans.